老年降压冲剂对脑梗死大鼠血浆雌二醇及内皮素的影响

Effect of Laonian Jiangya Chongji on plasma estradiol and endothelin in cerebral infarction rats

目的 探讨肾性高血压大鼠脑梗死缺血损伤时血浆雌二醇 (E2 )、内皮素 (ET)含量变化及老年降压冲剂对其的作用。方法 建立肾血管性高血压大鼠 ,复制出大鼠大脑中动脉闭塞模型 (MCAO) ,将其随机分为 3组 ,观察E2 ,ET含量变化。结果 MCAO血浆ET浓度显著升高 (P <0 .0 1) ,而E2 浓度显著下降 (P <0 .0 1) ;老年降压冲剂能升高血浆E2 浓度 ,降低ET浓度。结论 MCAO缺血损伤时 ,E2 ,ET起着重要作用 。

Objective It is to study the effect of Laonian Jiangya Chongji (LNJYCJ) on plasma estradiol (E 2) and endothelin (ET) in cerebral infarction rats. Methods The middle cerebral artery occluded (MCAO) rats were induced and divided into three groups. Changing E 2 and ET were observed. Results Plasma ET in MCAO increased significantly ( P <0.01), but E 2 in MCAO significantly decreased ( P <0.01). Conclusion E 2 and ET might play an important role in cerebral ischemic injury. LNJYHJ have preventive effect on cerebral ischemic injury.