摘要
Objective To detect the A/C1165 polymorphism of angiotensin Ⅱ type Ⅰ receptor (AT1-R)gene in essential hypertensive elderly. Methods The A/C1166 polymorphism of AT1-R gene was assessed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in a case-control study of 87 essential hypertensive elders (EH) and 55 normolensive elders (NT). Results The genotype frequencies of AA, AC, CC were 0 .805 , 0.161, 0 .034 in EH group and 0 .927 ,0 .073 ,0 .000 in NT group respectively. The frequency of C61166 allele was higher in EH group (0.115) than in NT group (0 .036 )(P<0 .05 ). Conclusion The resultsindicate that A/C1166 polymorphism of AT1-R gene may be associated with essential hypertension in elderly.
Objective:To detect the A/C^1166 polymorphism of angiotensin Ⅱ tyep 1 receptor(AT1-R) gene in essential hypertenive elderly.Methods:The A/C ^1166 polymorphism of AT1-R gene was assesed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) in a case-control study of 87 essential hypertensive elders(EH) and 55 normotensive elders(NT).Results:The genotype frequencies of AA,AC,CC were 0.805,0.161,0.034 in EH group and 0.927,0.073,0.000 in NT group respectively.The frequency of C^1166 allele was higher in EH group(0.115)than in NT group (0.036)(P<0.05).Conclusion:The resultsindicate that A/C^1166 polymorphism of AT1-R gene may be associated with essential hypertension in elderly.
