心肌梗死后心力衰竭患者血浆半乳糖凝集素3表达水平检测的意义

Expression of plasma Galectin-3 in patients with post-myocardial infarction heart failure

目的探讨心肌梗死后心力衰竭患者血浆半乳糖凝集素3(Galectin-3)的表达水平及临床意义。方法 60例心力衰竭患者根据其既往病史,分为陈旧性心肌梗死组和非心肌梗死组,各30例,分别检测血浆Galectin-3表达水平,应用超声心动图评价心脏结构和心功能。结果陈旧性心肌梗死组血浆Galecint-3表达水平显著高于非心肌梗死组[(28.88±9.78)μg/L比(22.57±4.59)μg/L,P<0.05]。陈旧性心肌梗死组左心室射血分数显著低于非心肌梗死组[(51.38±9.75)%比(58.90±4.62)%,P<0.05]。血浆Galectin-3表达水平与左心房前后径呈正相关(r=0.612,P<0.01),与左心室射血分数呈负相关(r=-0.389,P<0.05)。结论心肌梗死后心力衰竭患者的血浆Galectin-3的表达水平较高。

Objective To explore the expression and its clinical significance of plasma Galectin-3 in postmyocardial infarction heart failure. Methods Plasma Galectin-3 and two-dimensional echocardiographic parameters were measured in 60 patients with heart failure. All the participants were divided into OMI group( n = 30,mean age80. 21 ± 4. 59ys) and non-MI group( n = 30,mean age 80. 74 ± 2. 99ys) according to the medical history. Results In the OMI group,the expression level of plasma Galectin-3 was higher than that of the non-MI group( 28. 88 ± 9. 78μg /L vs 22. 57 ± 4. 59μg / L),the LVEF was lower than the non-MI group( 51. 38 ± 9. 75% vs 58. 90 ± 4. 62%). Plasma concentration of Galectin-3 was negatively correlated with left ventricular systolic function( r =- 0. 389,P < 0. 05),positively correlated with left atrial diameter( r = 0. 612,P < 0. 01). Conclusion Compared to the non-MI group,the level of plasma Galectin-3 in OMI group is higher.