高尿酸血症与体质量指数和脂代谢紊乱关系的临床研究

Clinical study of relationship between hyperuricemia and body mass index and dyslipidemia

目的了解人群中高尿酸血症(HUA)的分布,探讨其与体质量指数(BMI)及脂代谢紊乱间的关系。方法对健康体检资料完整的10 000名体检者的血清尿酸水平及相关临床指标进行统计分析。按照血清尿酸水平(SUA)将人群分组,比较不同血清尿酸水平人群间脂代谢及BMI的差异,并按照体质量数分组,比较不同体质量指数人群间高尿酸血症检出率的差异。结果 (1)10 000名人群中,高尿酸血症(HUA)者2619例,占26.2%。按年龄分层,各年龄组间男性HUA检出率无明显差异(χ~2=7.637,P=0.177);女性50岁后HUA检出率较50岁前各年龄组显著增加(χ~2=48.190,P=0.000;χ~2=14.567,P=0.002;χ~2=1.874,P=0.599);(2)HUA组的胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白、体质量指数(BMI)水平均显著高于非高尿酸组,高密度脂蛋白水平显著低于非HUA组(P<0.05);(3)HUA组高脂血症及超重、肥胖检出率显著高于非HUA组(P<0.05);(4)超重及肥胖人群HUA检出率显著高于BMI正常人群,且随BMI升高HUA检出率增高(P<0.05)。(5)Logistic回归显示:BMI、TC和TG是高尿酸血症发生的独立危险因素(P<0.05)。结论肥胖和高脂血症是发生高尿酸血症的危险因素。

Objective To investigate the distribution of hyperuricemia in population and explore the relationship between hyperuricemia and body mass index( BMI),lipid metabolism disorder. Methods Serum uric acid level and relevant clinical indexes of 10 000 individuals with complete data for health physical examination were collected and performs a statistical analysis. The difference of lipid metabolism and BMI were analyzed by serum uric acid level. Meanwhile the differences rate of HUA among populations with different BMI levels were compared. Results( 1) The incidence of HUA in 10 000 population was 26. 2%( n = 2619),furthermore,when stratified by age,there was no significant difference among different age group in the male,,but the incidence of women was increased with age after 50 years;( 2) In the HUA group,the level of serum TG,LDL and BMI were significantly higher than those in Non-HUA group,but the serum HDL level was lower than that in Non-HUA group;( 3) The detected rates of overweight,obesity and hyperlipidemia in HUA group were significantly higher than those in Non-HUA group;( 4) The detected rate of HUA in overweight and obesity groups were significantly higher than that in normal BMI group,the rate was increased with BMI;( 5) Logistic regression showed that BMI,serum TG and TC were independent risk factors of hyperuricemia. Conclusion Obesity and hyperlipidemia are the risk factors of hyperuricemia.