中心动脉压与颈动脉斑块的相关性研究

Correlation between central aortic pressure and carotid plaque

目的探讨中心动脉压(CAP)与颈动脉斑块的相关性。方法选取年龄≤75岁的患者136例,采用动脉脉搏波分析仪(Sphygmo Cor,Australia)测量CAP,颈动脉超声检查有无斑块形成。然后分为颈动脉正常组(60例)和颈动脉斑块组(76例),分析CAP相关参数对颈动脉斑块的影响及其相关性。结果与颈动脉正常组比较,颈动脉斑块组的年龄、冠心病患病率、高血压患病率、中心动脉脉压、增强压(AP)、增强指数均差异有统计学意义(P<0.05),中心动脉收缩压虽升高,但差异无统计学意义(P=0.69),外周肱动脉血压差异无统计学意义(P>0.05)。Logistic回归分析揭示,AP、总胆固醇和低密度脂蛋白是颈动脉斑块的独立危险因素。结论CAP是影响颈动脉斑块形成的危险因素。

Objective To explore the correlation between central aortic pressure and carotid plaque. Methods One hundred and thirty-six patients who were ≤75 years and hospitalized in our department were enrolled in this study from March,2013 to June,2015. The central aortic pressure was measured by Sphygmo Cor( Australia),and carotid plaque was examined by carotid ultrasound,respectively. The all subjects were divided into normal group( 60 cases)and carotid plaque group( 76 cases). Results Compared with normal group,the age,incidence rate of CHD,incidence rate of hypertensive,central aortic pulse pressure,augmentation pressure and augmentation index of central aortic increased significantly in the carotid plaque group( P < 0. 05). There was no difference in brachial artery pressure between two groups( P > 0. 05). Logistic regression analysis showed that augmentation pressure,TC,and LDL-C were independent risk factors of carotid plaque. Conclusion Central aortic pressure is an independence risk factor of carotid plaque.