基于关联规则对不同年龄段强直性脊柱炎患者血小板参数及免疫炎症代谢指标的数据挖掘

Data mining of platelet parameters and immune inflammatory metabolic parameters in patients with ankylosing spondylitis at different age based on association rules

目的应用关联规则分析不同年龄强直性关节炎(AS)患者血小板参数及免疫、炎症、代谢指标。方法整理2012年6月至2017年7月安徽省中医院风湿科AS患者临床诊治的病历资料。年龄<35岁者为青年组,35≤年龄<45者为中年组。结果①共检索出AS患者816例,其中青年组546例,中年组270例,两组患者性别、病程均差异无统计学意义。②中年组患者的血小板计数、血小板平均体积、总胆固醇及三酰甘油的异常率均较青年组高。③血小板压积(PCT)与C反应蛋白(CRP)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、补体C3、补体C4成正相关,与TG成负相关; PCT与CRP、IgA、IgG、C3、C4成正相关;血小板分布宽度(PDW)与CRP、IgA、IgG、C3、C4、三酰甘油(TG)成负相关,与IgM成正相关;血小板平均体积(MPV)与CRP、IgA、IgG、C3、C4、TG成负相关,与IgM、TG成正相关(P <0. 05或P <0. 01)。④IgG&C3组合、C4&C3组合、C3&CRP组合、C3&ESR组合、C3&年龄组合与PLT关联度较高; IgG&CRP组合、IgG&ESR组合、C3&病程组合、C3&年龄组合、C4&病程组合与PCT关联度较高。结论血小板参数的变化与免疫、炎症、代谢及年龄、病程均有关,且与免疫、炎性反应关系密切,且随着年龄、病程的增长,血小板参数及代谢指标的异常改变随之增加。

Objective To analyze the influence of platelet parameters and immune inflammatory metabolic parameters in patients with ankylosing arthritis at different ages by using association rules and statistical methods. Methods The electronic data of clinical diagnosis and treatment of patients with rheumatism in the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from June 2012 to July 2017 were collected. The younger than 35 years old is the youth group,and the younger than 35 is the middle-aged group. Results ①A total of 816 AS patients were retrieved,including 546 in the young group and 270 in the middle-aged group. There was no significant difference in the gender and course of the disease between the two groups. ②The platelet count,average platelet volume,total cholesterol,and triglyceride abnormalities were higher in the middle-aged group than in the young group. ③PLT was positively correlated with CRP,IGA,IGG,C3,C4 and negatively correlated with TG;PCT was positively correlated with CRP,IGA,IGG,C3,C4;PDW was negatively correlated with CRP,IGA,IGG,C3,C4,TG Positive correlation with IGM;MPV was negatively correlated with CRP,IGA,IGG,C3,C4,TG,and positively correlated with IGM and TG( P < 0. 05 or P < 0. 01).④IGG&C3 combination,C4&C3 combination,C3&CRP combination,C3&ESR combination,C3&age combination and PLT have higher correlation;IGG&CRP combination,IGG&ESR combination,C3&range combination,C3&age combination,C4&range combination and PCT have higher correlation. Conclusion The changes of platelet parameters are related to immune inflammation metabolism,age and course of disease,and are closely related to the immune and inflammatory response. They may be involved in the pathogenesis of AS disease,and the abnormal rate of platelet parameters and metabolic indicators increases with age and disease duration.