急性冠脉综合征患者血清CD105水平测定及意义

The significance of serum CD105 level in patients with acute coronary syndrome

目的探讨急性冠脉综合征患者血清CD105水平及意义。方法分别对临床诊断的86例急性冠脉综合征患者、86例稳定性心绞痛患者及60例健康自愿者,采血检测血清CD105与超敏C反应蛋白(hs-CRP)水平。结果 (1)急性冠脉综合征组患者血清CD105水平显著高于稳定性心绞痛组患者及健康对照组(分别为(5. 12±2. 76)μg/L、(1. 32±0. 76)μg/L、(0. 82±0. 36)μg/L,P均<0. 01),稳定性心绞痛组与健康对照组间血清CD105水平差异无统计学意义(P> 0. 05);(2)急性冠脉综合征组血清hs-CRP水平显著高于稳定性心绞痛组及健康对照组[分别为[(16. 12±5. 06) mg/L、(4. 26±1. 25) mg/L、(2. 26±1. 62) mg/L,P均<0. 01],稳定性心绞痛组与健康对照组间血清hs-CRP水平差异无统计学意义(P> 0. 05);(3)急性冠脉综合征组患者血清CD105与hs-CRP水平呈正相关(r=0. 812,P <0. 01)。结论血清CD105有望成为早期识别急性冠脉综合征的敏感标志物。

Objective To study the significance of serum CD105 in patients with acute coronary syndrome( ACS). Methods Serum CD105 and high sensitivity C-reactive protein( hs-CRP) were both examined in eighty-six patients with acute coronary syndrome,eighty-six patients with stable angina( SA) and sixty healthy volunteers individually. Results( 1) The serum CD105 level in ACS group was higher than that in both SA group and the control group significantly( 5. 12 ± 2. 76) μg/L,( 1. 32 ± 0. 76) μg/L and( 0. 82 ± 0. 36) μg/L,respectively,all P < 0. 01). There was no significant difference in the CD105 level between SA group and the control group( P > 0. 05).( 2) The serum hs-CRP level in ACS group was higher than that in both SA group and the control group significantly( 16. 12 ± 5. 06)mg/L,( 4. 26 ± 1. 25) mg/L and( 2. 26 ± 1. 62) mg/L respectively,P < 0. 01). There was no significant difference in the hs-CRP level between SA group and the control group( P > 0. 05).( 3) The level of serum CD105 was positively correlated with the hs-CRP level in ACS group( r = 0. 812,P < 0. 01). Conclusion Serum level of CD105 is a promising sensitive marker for early identification of acute coronary syndrome.