摘要
Insulin-like growth factor 1(IGF-1) is a pluripotent growth factor,with multiple functions in the peripheral and central nervous systems. Increasing evidence suggests that IGF-1 fine-tunes the development of the central nervous system,ensuring proper neuronal differentiation,maturation,and connectivity. It supports neuronal survival and axon growth,and acts on myelinating Schwann cells and oligodendroglia. The biological functions of IGF-1 are modulated by the IGF-1 signaling pathway. Recent studies have proposed the modulation of the members of the IGF-1/IGF-1 signaling pathway as treatment for neuropathologies. In this study,we introduce the structure of IGF-1/2 and its receptors,with the intra-cellular interactions. Further,we review the therapeutic effects of IGF-1 in different models of brain diseases,via activation of different cellular mechanisms.
Insulin-like growth factor 1(IGF-1) is a pluripotent growth factor,with multiple functions in the peripheral and central nervous systems. Increasing evidence suggests that IGF-1 fine-tunes the development of the central nervous system,ensuring proper neuronal differentiation,maturation,and connectivity. It supports neuronal survival and axon growth,and acts on myelinating Schwann cells and oligodendroglia. The biological functions of IGF-1 are modulated by the IGF-1 signaling pathway. Recent studies have proposed the modulation of the members of the IGF-1/IGF-1 signaling pathway as treatment for neuropathologies. In this study,we introduce the structure of IGF-1/2 and its receptors,with the intra-cellular interactions. Further,we review the therapeutic effects of IGF-1 in different models of brain diseases,via activation of different cellular mechanisms.
基金
2013 Project of six peak talents in Jiangsu Province,Project number: WSN-022
2017 Project of Northern Jiangsu People’s Hospital,Project number: yzucms201712
Standard Diagnosis and Treatment Project of scientific technology and social development in Yangzhou. Project number: YZ2015046
