多元分析法探讨慢性肾衰竭血液透析患者中医证候特点

Multivariate Analysis of TCM Syndromes in Patients with Chronic Renal Failure Undergoing Hemodialysis

目的:通过采用多元分析方法探讨慢性肾衰竭血液透析患者的中医证候特点,旨在为透析后患者的中医药治疗提供依据和基础。方法:通过调查问卷的方法,收集终末期肾病维持性血液透析患者临床症状,包括年龄、性别、血液透析病程、原发病、相关实验室检查数据、中医证候等,采用多元统计方法进行分析,探讨慢性肾衰竭血液透析患者中医证候特点。结果:采集了160例于上海中医药大学附属岳阳中西医结合医院维持性血液透析患者调查问卷,通过频数分析、因子分析及聚类分析等统计方法,将维持性血液透析患者中医证候分为:气血两虚证、湿热蕴结证、瘀血阻络证、阴虚风动证。结论:血液透析患者中医证型分布与年龄、血清钾离子水平、血清铁离子水平有关,原发病、透析龄也可能是影响维持性血液透析患者中医证型分布的原因。

Objective:To provide theoretical support and base for the chronical renal failure(CRF)after hemodialysis to turn to TCM treatment by investigating and arguing the characteristics of TCM syndromes of CRF patients with multivariable analysis method. Methods:Gathered the clinical syndrome of maintenance hemodialysis patients(MHP)in the end stage including age gender hemodialysis original disease relative laboratory measure data TCM syndromes and so on by the way of questionnaire and applied multivariable analysis method to investigate and argue the characteristics of TCM syndrome and sign of CRF patients. Results:Collected 160 MHP questionnaires complying with the inclusion criteria from Yueyang combination of Western medicine and TCM hospital subsidiary to Shanghai TCM university. Divided the syndromes of the 160 MHPs into Qi-blood deficiency syndrome, damp-heat accumulation syndrome, blood stasis obstruction syndrome, Yin deficiency and wind movement syndrome. Conclusion:The syndromes of MHP may relate with the age,the level of ion potassium in serum and the level of ion iron in serum,at the same time the original disease hemodialysis time might also have an effect on the maintenance of syndrome and sign of MHP.