苦参活性物调控肿瘤细胞自噬研究进展

Advances in Studies on Sophora Flavescens Active Substance Regulating Autophagy in Tumor Cell Lines

自噬是机体在缺氧和饥饿等恶劣环境状态下,维持细胞正常功能和内环境稳态的一种自我保护机制。它在细胞的生物合成、营养和代谢平衡及应激反应与存活中起着重要的作用,因此自噬是癌细胞代谢适应的重要机制。中药苦参在作用不同的肿瘤细胞系时,可能会诱导细胞自噬的发生,这种自噬机制可能对肿瘤起着促进作用或抑制作用。该文对苦参中具有代表性两种活性物质苦参碱和槲皮素,从自噬性死亡抑制肿瘤细胞增殖或促进凋亡和保护性自噬延缓或抑制凋亡两方面的研究进展进行了综述,为中药调控细胞自噬的相关研究提供参考。

Autophagy is a kind of self-protective mechanism to maintain the normal function and homeostasis of cells under the condition of hypoxia and starvation,it plays an important role in cell biosynthesis,nutritional and metabolic balance,stress and survival,therefore,it is an important mechanism of metabolic adaptation of autophagy cancer cells.Sophora flavescens may induce autophagy in different tumor cell lines,which may promote or inhibit the tumor.In this paper,two representative active substances of Sophora flavescens,matrine and quercetin,were reviewed from two aspects of autophagic death inhibiting tumor cell proliferation or promoting apoptosis and retarding or inhibiting apoptosis by protective autophagy,it provides a reference for the study of regulation of cell autophagy by traditional chinese medicine.