痰菌阳性肺结核患者血中IL-10的表达及意义

Significance and secretion level of IL-10 in pulmonary tuberculosis patients with bacteria positive in sputum

目的探讨白细胞介素-10(IL-10)在痰菌阳性肺结核患者血浆中的表达水平及其意义。方法ELISA检测肺结核患者18例(初治组11例、复治组7例)、健康体检者18例血浆中IL-10的水平。结果血浆中IL-10水平在肺结核患者组为(13.34±3.66)pg/mL,肺结核初治组为(13.55±3.40)pg/mL,肺结核复治组为(15.58±3.60)pg/mL,均显著高于健康对照组的(8.58±3.04)pg/mL(P<0.01)。结论肺结核患者血浆中IL-10的水平升高,参与结核病的损伤过程与进展。

Objective To investigate the significance and secretion level of interleukin-10(IL-10)in plasma on pulmonary tuberculosis patients with bacteria positive in sputum.Methods The IL-10 in plasma were detected with ELISA in 18 pulmonary tuberculosis patients(11 patients of initial treatment group and 7 patients of re-treatment group) and 18 healthy individuals.Results The secretion levels of IL-10 in plasma of pulmonary tuberculosis group(13.34±3.66 pg/mL) was significantly higher than in the healthy control group(8.58±3.04 pg mL)(P <0.01).The IL-10 levels in plasma of pulmonary tuberculosis patients with initial treatment group(13.55±3.40pg/mL) and re-treatment group(15.58±3.60 pg/mL) were obviously higher than in the healthy control group(P <0.01).The level of IL-10 in pulmonary tuberculosis patients with re-treatment group was the highest of all groups.Conclusion In pulmonary tuberculosis patients,the higher IL-10 level can mediate the process and progress of tuberculosis injury.