艾灸对便秘临床疗效的Meta分析

A Meta-analysis of clinical efficacy of moxibustion on constipation

目的对艾灸治疗便秘的临床随机对照试验进行疗效评价,为艾灸治疗便秘的临床决策提供思路与参考。方法通过计算机检索PubMed、Medline、Cochrane Library、中国知网、万方、维普等数据库,筛选符合文献纳入标准的随机对照实验,运用CLEAR NPT系统对其进行质量评价,对符合标准的文献进行Meta分析。结果共检索文献473篇。结合纳入与排除标准进行筛选,最终剩余17篇(1 129例患者)。Meta分析可知:试验组患者便秘治疗有效率高于对照组患者(OR=3.77,95%CI:[2.68,5.31],P <0.000 01);试验组患者结肠传输试验结果优于对照组患者(WMD=-4.67,95%CI:[-5.38,-3.95],P <0.000 01);试验组患者排便障碍结果优于对照组患者(WMD=-6.80,95%CI:[-8.63,-4.96],P <0.000 01),差异均具有统计学意义(P <0.05)。结论艾灸治疗便秘临床效果明显,但当前相关研究文献整体质量不高,今后仍需大样本、多中心、高质量的随机对照试验进一步验证。

Objective To evaluate the efficacy of clinical randomized controlled trials of moxibustion for constipation,to provide ideas and references for the clinical decision-making therein.Methods The databases of PubMed,Medline,Cochrane Library,China National Knowledge Infrastructure,Wanfang Datebase,Weipu Datebase,etc.were searched by computer,randomized controlled trials that met the inclusion criteria of the literature were Meta-analysised experimental and were screened and evaluated by the CLEAR NPT system.Results 473 documents were retrieved.Combined with the inclusion and exclusion criteria,the final remaining 17 articles(1 129 patients)were screened.The Meta-analysis showed that the effective rate of constipation treatment in the group was higher than that in the control group(OR=3.77,95%CI:[2.68,5.31],P<0.000 01),the results of colonic transit test in the experimental group were better than those in the control group(WMD=-4.67,95%CI:[-5.38,-3.95],P<0.000 01),the results of defecation disorder in the experimental group were better than those in the control group(WMD=-6.80,95%CI:[-8.63,-4.96],P<0.000 01),all with statistical significance(P<0.05).Conclusion The effect of moxibustion on constipation is precise,but the current literature is of poor quality.In the future,more large-sample,multi-center and high-quality randomized controlled trials are needed for further verification.