早期循环式腹腔热灌注化疗对胃癌合并腹腔积液患者血清MMPs与CEA的影响

Influence of early circulating abdominal hot perfusion chemotherapy in treatment of patients with gastric cancer combined abdominal cavity effusion of serum MMPs and CEA

目的探讨早期循环式腹腔热灌注化疗对胃癌合并腹腔积液患者血清基质金属蛋白酶(MMPs)与癌胚抗原(CEA)的影响。方法选取2013年3月—2014年4月收治的胃癌合并腹腔积液患者100例,按照化疗方式分为试验组和常规组,每组50例,试验组给予早期循环式腹腔热灌注化疗治疗,常规组给予常规灌注化疗治疗,比较2组血清MMPs与CEA水平、疗效、预后、不良反应情况。结果试验组治疗后血清MMP-2、MMP-7、MMP-9及CEA水平均明显低于常规组,差异有统计学意义(P <0.05)。试验组腹腔积液消退有效率明显高于常规组,差异有统计学意义(P <0.05);试验组2年内复发率、转移率明显低于常规组,试验组2年生存率明显高于常规组,差异有统计学意义(P <0.05);试验组不良反应发生率明显低于常规组,差异有统计学意义(P <0.05)。结论早期循环式腹腔热灌注化疗能更有效降低胃癌合并腹腔积液患者血清MMPs、CEA水平,有利于提高化疗效果和改善预后,且安全性高。

Objective To discuss the effect of early circulating abdominal hot perfusion chemotherapy on serum matrix metalloproteinase(MMPs)and carcinoembryonic antigen(CEA)in patients with gastric cancer combined abdominal cavity effusion.Methods From March 2013 to April 2014,100 patients with gastric cancer combined abdominal cavity effusion were selected and were divided into an experimental group and routine group according to their modes of chemotherapy,with 50 cases in each group.The routine group was given routine perfusion chemotherapy and the experimental group was given early circulatory abdominal hot perfusion chemotherapy.The serum MMPs and CEA levels,therapeutic efficacy,prognosis and adverse reactions were compared between them.Results The levels of serum MMP-2,MMP-7,MMP-9 and CEA in the experimental group after treatment were significantly lower than those in the routine group and the difference was statistically significant(P<0.05).The effective rate of peritoneal effusion in the experimental group was significantly higher than that in the routine group and the difference was statistically significant(P<0.05).The recurrence rate and metastasis rate within 2 years in the experimental group were significantly lower than those in the routine group,and the 2-year survival rate in the experimental group was significantly higher than that in the routine group,with the difference being statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was significantly lower than that in the routine group,with the difference being statistically significant(P<0.05).Conclusion Early circulating abdominal hot perfusion chemotherapy can effectively reduce the serum MMPs and CEA levels in patients with gastric cancer combined abdominal cavity effusion,is helpful to improve the chemotherapy effect and prognosis,and is of a higher safety.