肠道菌群在非酒精性脂肪性肝病的发病和治疗中的作用机制

Mechanism of action of gut microbiota on the pathogenesis and treatment of non-alcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗和遗传易感密切相关的代谢应激性肝损伤,患病率逐年增长,并呈现低龄化。NAFLD的发病机制尚未完全阐明,目前认为与肥胖、胰岛素抵抗、高脂血症及遗传等因素相关。随着'肠—肝轴'学说的提出,大量的研究逐渐证实肠道菌群在NAFLD发病机制中有作用,针对肠道菌群的调节对于NAFLD的治疗价值被不断探索。

Non-alcoholic fatty liver disease(NAFLD)is a metabolic stress injury to the liver closely related to insulin resistance and genetic susceptibility.Its prevalence has increased year by year and is showing people of young age.The pathogenesis of NAFLD has not yet been fully elucidated and is currently thought to be related to factors such as obesity,insulin resistance,hyperlipidemia and heredity.With the introduction of the'intestinal-hepatic axis'theory a large number of studies have gradually confirmed the role of intestinal flora in the pathogenesis of NAFLD and further regulation of the therapeutic value of intestinal flora for the treatment of NAFLD has been continuously explored.