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Adaptive designs for sequential experiments 被引量:3

Adaptive designs for sequential experiments
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摘要 Various adaptive designs have been proposed and applied to clinical trials, bio assay, psychophysics, etc.Adaptive designs are also useful in high cost engineering trials.More and more people have been paying attention to these design methods. This paper introduces several broad families of designs, such as the play-the-winner rule, randomized play-the-winner rule and its generalization to the multi-arm case, doubly biased coin adaptive design, Markov chain model. Various adaptive designe have been proposed and applied to clinical trials,bioassay,psycho-physics,etc.Adaptive designs are also useful in high cost engineering trials.More and More people have been paying attention to these desing methods.This paper introduces several broad families of designs,such as the play-the-winner rele,randomized play-the-winner rule and its generalization to the multi-arm case,doubly bi-ased coin adaptive design,Markov chain model.
出处 《Journal of Zhejiang University Science》 EI CSCD 2003年第2期214-220,共7页 浙江大学学报(自然科学英文版)
关键词 Clinical trial Adaptive designs (Randomized) Play-the-winner rule Biased coin design Markov chain Asymptotic properties Urn model. 连续实验设计 适应性设计 临床试验 马尔可夫链模型
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