Fas和FasL表达与膀胱癌的浸润与复发

Fas AND FasL GENE EXPRESSION IN BLADDER CELL CARCINOMA

目的 :探讨凋亡相关基因产物 Fas和 Fas L 在膀胱癌中表达与膀胱癌浸润、复发生物学行为的关系。方法 :用免疫组化方法检测 4 6例膀胱癌标本中 Fas和 Fas L 的表达 ,并与膀胱癌的浸润深度 (临床分期 )及随访结果相比较。结果 :Fas在复发组和非复发组中的表达差异有统计学意义 (P <0 .0 5 ) ,复发组的 Fas表达强度明显下降。Fas L 在浸润型组和浅表型组中表达差异有统计学意义 (P <0 .0 5 ) ,浸润型组中 Fas L 表达强度明显增加。结论 :Fas和 Fas L 介导的肿瘤细胞凋亡在膀胱癌中受到抑制 ,Fas和 Fas L 的表达可以作为判断膀胱癌浸润深度。

Objective:To investigate Fas and FasL gene expression and to evaluate their significance on the biological behavior of the bladder tumor Methods:Fas and FasL gene expression were detected in 46 specimens of bladder carcinoma by means of immunohistochemical SP Results:The expression of Fas between recurrent group and norecurrent group was significantly different(P<0 05);Fas expression rate in recurrent group was lower The expression of FasL between infiltrating group and superficial group was significantly different(P<0 05);FasL expression rate in infiltrating group was higher Conclusions:Fas and FasL induced cell death was inhibited in bladder carcinoma.The expression of Fas and FasL had a practical significance in assessing bladder carcinoma malignance and recurrence