摘要
将细粒棘球绦虫 (E.g)虫卵在孵化脱壳后 ,通过腹腔、静脉或皮下注入鼠体内 ,使其发育为包囊 ,这一动物模型的建立为人们对宿主免疫反应的研究提供了新的领域和前景。本论文通过静脉、腹腔、皮下感染六钩蚴及口服感染虫卵 4种途径感染昆明小鼠 ,感染率分别达到 10 0 %、10 0 %、83 %和 81% ,建立了适合新疆家养绵羊株 E.g的模型小鼠。并对六钩蚴感染方式与产生包囊寄生部位的对应关系以及寄生在不同部位包囊的生长状况进行比较分析。为包虫病生物学及免疫学的进一步深入研究奠定基础。
Mice were infected with hatched oncospheres of Echinococcus granulosus, and obtained 100% infection by intraperitioneal (i.p.) and intravenous (i.v.) injection respectively. Subcutaneous (s.c.) or oral infection gave 83% and 81% infection, respectively. Cysts were exclusively grown in the lung and thoracic cavity by i.v. injection. With i.p. or s.c. injection, cysts were located in the injection position.
出处
《中国兽医寄生虫病》
2003年第2期9-12,F002,F003,共6页
Chinese Journal of Veterinary Parasitology
基金
Wellcome trust项目基金资助
