头孢硫脒等6种抗菌药物对革兰氏阳性球菌体外抗菌活性研究

Study on the in vitro antibacterial activity of cefathiamidine and other five antimicrobial agents against Gram-positive cocci

目的 对比研究头孢硫脒 (CTM )、头孢唑林 (CEZ)、头孢呋辛 (CXM )、头孢曲松 (CRO )、苯唑西林 (MPIPC)、万古霉素 (VCM )对 99株临床分离革兰氏阳性球菌的抗菌活性。方法 采用琼脂平板稀释法测定最低抑菌浓度 (MIC)。结果 CTM对 3 2株金黄色葡萄球菌的MIC50 、MIC90 均为 0 5mg/L ,低于CRO ,CTM对 2 9株表皮葡萄球菌的MIC50 、MIC90 分别为 0 12 5和 8mg/L ,是CRO的 1/16,对 9株甲氧西林耐药的葡萄球菌 (MRS)的范围与CXM相近 ;CTM对粪肠球菌的抗菌活性与万古霉素相仿 ,强于CEZ、CXM、CRO、MPIPC。结论 头孢硫脒对葡萄球菌和粪肠球菌具有很强的体外抗菌活性。

Objective The in vitro antibacterial activity of cefathiamidine(CTM), cefazolin(CEZ), cefuroxime (CXM), ceftriaxone(CRO), oxacillin(MPIPC) and vancomycin (VCM) against 99 clinical strains of Gram-positive coccus was studied. Methods MICs were determined by agar dillution method. Results The MIC 50 and MIC 90 of CTM against Staphylococcus aureus (n =32) was 0.5mg/L, less than CRO, and that against Staphylococcus epidermidis ( n =29) was 0.125 and 16mg/L, less than that of CRO while the MIC range of CTM against methicillin-resistant Staphylococcus (MRS, n =9) was 1～128 mg/L. CTM and VCM had the similar antibacterial activiy against Enterococcus faecalis (n =29), higher than CEZ, CXM, CRO and MPIPC. Conclusion The antimicrobial activity of CTM against Staphylococcus spp. and Enterococcus faecalis was excellent .