四君子汤对抗生素脱污染小鼠肠道菌群失调的预防作用

PREVENTION OF SI JUNZI TANG ON ALTERATION OF INTESTINAL FLORA IN MOUSE MADE BY ANTIBIOTIC

目的 :观察四君子汤在小鼠肠道正常菌群失调形成过程中的作用 ,为进一步开发中药四君子汤提供理依据。方法 :将小鼠分为正常对照组、抗生素造型组、中药预防组。预防组先给予四君子汤 ,3d后在给予四君子汤的同时 ,与抗生素造型共同给予盐酸林可霉素。 3d后进行肠道菌群检测。结果 :预防组小鼠肠道菌群受抗生素影响小 ,与抗生素造型组比较差异显著 (p <0 .0 0 1>)。结论

Objective:Observe action of Chinese drugs Si Junzi Tang in the course of alteration of intestinal flora in mouse. Give the oretical certification for advance Si Junzi Tang . Methods: The mouse were divided in three groups: normal concrol group,antibiotic for molding group and Chinese drug preveniton group. Prevention group were given Si Junzi Tang first, three days later,the latter two groups were given lincomycin together. Then the intestinal flors detection were taken. Results:Intestinal flora quantity of Chinese drug prvevntion group were significant more than that of antibiotic for molding group (p<0.001).Conclusion:SiJunzi Tang have prevention action on alteration of intestinal flora model made by antibiotic.