摘要
目的 评价静滴胺碘酮对瓣膜置换术后房颤患者凝血酶原时间 (PT)变化的影响。方法 选择风湿性心脏病机械瓣膜置换术后合并快速房颤患者 33例 ,患者均接受静滴胺碘酮治疗 5d ,于静滴胺碘酮前后检查凝血酶原时间。结果 常规剂量华法林抗凝情况下 ,33例患者中PT全部延长。静滴胺碘酮前PT为 (2 1.2± 3.1)s,静滴胺碘酮后PT为 (35 .2±6 .1)s,前后相差显著 ,(P <0 .0 5 )。结论 风湿性心脏病机械瓣膜置换术后合并快速房颤患者在应用胺碘酮静滴治疗快速房颤时 ,应用常规剂量华法林抗凝可使PT明显延长。
Objective To evaluate the effct of intravenous amiodarone on prothrombin time (PT) in patients after valve replacement.Methods Intravenous amiodarone was administered to 33 atrial fibeillaion patients with rheumatic heart disease and mechanical valve replacement for 5 days,and PT was detected in every patient before and after amiodarone uses.Results PT was (21.2±3.1)s before amiodarone use and became (35.2±6.1)s after ordarone use,on condition of routine warfarin administraion.Yhe latter is significantly longer than the former( P <0.05).Conclusion PT become signifcantly loger after intravenous amiodarone adminstration to atrial fibrillation patents with rheumatic heart disease and mechanical valve replacement on condition of routine warfarin administration.
出处
《临床军医杂志》
CAS
2003年第2期15-16,共2页
Clinical Journal of Medical Officers
