高能冲击波致肾损伤的实验研究

The experimental study of renal damage induced by high energy shock wave

目的 探讨高能冲击波致肾脏损伤的作用机制。方法 对 15只家兔进行体外冲击波碎石术 (ESWL) ,观察ESWL前后不同时间血和肾组织匀浆中内皮素 1(ET 1)、超氧化物歧化酶 (SOD)和丙二醛 (MDA)变化及肾组织病理学改变。结果 ESWL后血和肾组织匀浆中ET 1、MDA显著性升高 (P <0 .0 5 ) ,升高持续 1周。而血浆和肾组织匀浆中SOD显著性降低 (P <0 .0 5 )。病理检查出现不同程度肾损伤。结论 高能冲击波致肾脏损伤与自由基形成、内皮素升高引起肾血流下降有关。

Objective To study the mechanism of renal damage induced by high energy shock wave. Methods Fifteen rabbits received extracorporeal shockwave lithotripsy (ESWL) in the right kidney by using MZ V lithotriptor. Plasma and on renal tissue ET 1, SOD, serum and on renal tissue MDA were determined and renal morphlogy was observed. Results Plasma ET 1 and serum MDA and both on renal tissues increased significantly, while plasma and renal tissue SOD decreased significantly ( P < 0.05 ) after ESWL. Histological changes included injury of glomerular basal membrane (GBM), interstitial congestion, segmental renal tubular necrosis, focal connective tissue proliferation in renal medulla. Conclusion High energy shock wave inducing renal damage is associated with free radical formation, endothelin release, and decrease of renal plasm flow.