环氧合酶-2抑制剂防治阿尔茨海默氏病的进展

Progress of cyclooxygense-2 inhibitors in treatment of Alzheimer's disease

阿尔茨海默氏病 (Alzheimer’sdisease,AD)是最常见的一种老年期痴呆综合症 ,它的发生与炎症密切相关。炎症过程在阿尔茨海默氏病的退行性变和认知功能障碍的发病机理中起了关键性的作用。据报道 ,环氧合酶 2 (COX 2 )抑制剂在延缓AD病的进程和改善认知能力上是很有效的。

Alzheimer's disease (AD) is the most common cause of dementia in the elderly population. The occurrence of dementia correlates with inflammation. Inflammation processes may play a critical role in the pathogenesi s of the degenerative changes and cognitive impairments associated with Alzheime r's disease. Cyclooxygense-2 (COX-2) inhibitors are reported to be e ffective in reducing the risk of developing AD or cognitive impairments. Studies on this field are of important significance in the understanding the pathogenes is and therapeutic measures for AD. This review will discuss the progress in the treatment of Alzheimer's disease by COX-2 inhibitors.