复方α-酮酸片治疗慢性肾功能不全胱抑素-C改变的临床研究

Efficacy of ketosteril in treatment of chronic renal failure with h igh level of plasma Cys-C

目的 :观察复方α 酮酸片治疗慢性肾功能不全的临床效果及对胱抑素 (Cys C)改变的影响。方法 :选择慢性肾功能不全患者 60例 ,简单随机分成治疗组 3 0例及对照组 3 0例 ,对照组采取低蛋白低磷饮食治疗及西医对症处理 ;治疗组在对照组的基础上结合复方α 酮酸片治疗 ;选取正常体检者 3 0例作为正常组 ,观察 (Cys C)、Scr、TC、HB、HDL治疗前后的变化 ,Cys C采用乳胶颗粒增强比浊法测定 ,Scr、TC、HB、HDL采用常规方法测定。结果 :治疗组和对照组治疗前后各项指标相比均有所改善 ,治疗组治疗后Cys C、Scr水平明显下降 (P <0 .0 5 )。结论 :复方α 酮酸片能改善患者肾功能、血脂紊乱和营养状况 ,并为Cys

AIM: To observe the efficacy of ketosteril in treatm en t of chronic renal failure with high level of plasma Cys-C. METHODS: 60 patients with chronic renal failure were randomly divided into treatmen t group and control group. The control group was adopted a low protein and low p hosphorum diet and correcting symptoms; the treatment group, based on the therap y of the control group, was given ketosteril; 30 healthy subjects were used as t he normal control to observe changes of Cys-C, Scr, TC, HB, and HDL before and after the treatment. RESULTS: The levels of Cys-C and Scr decre ased after the administration of ketosteril (P< 0.05 ). CONCLUSION: Ketosteril shows a better effect on decreasing the levels of Cys-C and Scr in patients with CRF.