三七皂苷对肾性高血压大鼠血压的影响

Pharmacologic effects of PNS on rats with renal hypertension

目的 研究三七皂苷 (PNS)对肾性高血压大鼠血压及肾脏一氧化氮 (NO)、超氧化物歧化酶 (SOD)含量的影响。方法 2 4只大鼠随机分组 :①假手术组 ;②手术对照组 ;③PNS2 0 0mg·kg-1组④PNS40 0mg·kg-1组。各组术前在清醒状态下测大鼠尾动脉血压。建立大鼠肾动脉狭窄性高血压模型 ,肾脏NO含量采用NO代谢产物硝酸盐法测定 ,按Narklund法测定SOD活力。观察PNS对高血压大鼠的血压及肾匀浆中NO、SOD水平的影响。结果 (1)PNS能明显降低肾性高血压大鼠血压 ,与手术对照比较有显著差异 (P <0 0 1) ,(2 )手术对照组狭窄侧肾脏重量明显低于假手术对照组及未狭窄侧 (P <0 0 1)。 (3 )PNS能明显增加肾组织NO、SOD含量与手术对照组比较有明显区别 (P <0 0 1)。结论 PNS能明显降低肾动脉狭窄性高血压、增加NO含量、增强抗氧化能力。

Objective: To study the effect of panax notoginseng saponins (PNS) on the blood pressure and the NO?SOD-content in kidneys of rats with angiostenosis hypertension Methods: Twenty-four Wister rats were randomly divided into non-stenosis,stenosis control,PNS 200 mg·kg -1 and PNS 400 mg·kg -1 groups The blood pressure of caudal artery was measured with SJ-42 multifunctionnal recqrder and the contents of NO and SOD in kidney were also determined Results: (1) PNS obviously reduced the blood pressure of renal hypertensive rats(P<0 01 vs controls) (2)The kidney weight in rats with stenosis of renal artery was much lower than that in those without stenosis; (3) PNS significantly increased NO and SOD contents in kideney (P<0 01 vs controls) Conclusion: The blood pressure-depressing effect of PNS may be related to inhibiting the inflow of Ca ++ ,increasing the NO content ,strengthing the antioxygening ability and protecting the endotheliocyte of blood vessels