苯骈三氮唑胺烷基化及N-取代芳胺的简便合成

The Aminoalkylation of Benzotriazole and Synthesis of N-Substituted Arylamines

苯骈三氮唑、胺和甲醛在乙醇溶液中发生Mannich反应,生成胺烷基化的苯骈三氮唑衍生物.胺可以是芳香或杂环一级、二级胺,产率很高.上述反应生成的苯骈三氮唑衍生物在硼氢化钠作用下或与格氏试剂反应生成二级或三级芳胺,该法操作简便,条件温和,无副反应.

The aminoalkylation of benzotriazole derivatives was obtained from benzotriazole, amines and formaldehyde in alcohol by Mannich type condensation. This method gives good yields. Furthermore, all derivatives could be reduced by NaBH4 and reacted with Grignard agents in THF to give secondary or tertiary amines, they gave mild reaction conditions and high yields.