四抗感冒口服液镇痛作用的实验研究

Analgesic effect of Sikang ganmao oral liquores

目的 研究四抗感冒口服液 (CCD)的镇痛作用。方法 应用热诱发小鼠疼痛反应模型和冰醋酸诱导小鼠扭体反应模型观察CCD对疼痛的抑制作用。结果 CCD 5 0 g/kg和 10 0 g/kg可明显延长小鼠热痛反应潜伏期 (P <0 0 5 ,P <0 0 1) ,提高小鼠的痛阈值 ,且维持时间较阿司匹林长 ;CCD 10 0 g/kg与 2 0 0g/kg对小鼠扭体反应次数有明显抑制作用 (P <0 0 1)。 结论 CCD具有镇痛作用 ,且作用维持时间较长。

Objective To study the effects of Sikang ganmao oral liquores(CCD) on analgesia.Methods Model of the acetic acid induced writhing in mice and the method of hot plate in mic e were used.Results CCD 5.0 and 10.0 g/kg enhanced incubation p eriod of hot plate reaction in mice(P<0.05,P< 0.01).CCD 10.0 and 20.0 g/kg showed marked suppressive effect on writhing induce d by acetic acid in mice(P<0.01).Conclusion CC D possesses analgesic effect which could maintain longer time.