丙型病毒性肝炎与性传播关系的临床研究

STUDIES ON SEXUAL TRANSMISSION OF HEPATITIS C VIRUS

目的 研究丙型病毒性肝炎与性传播的关系。方法 应用逆转录巢式聚合酶链反应 (RT PCR)检测丙型病毒性肝炎患者、性病患者精液以及阴道分泌物中HCVRNA。应用ELISA法检测其配偶的抗 HCV ,并与正常健康夫妇 18对作对照观察。结果 ① 3 3例男性丙型病毒性肝炎患者精液中HCVRNA阳性 6例 (18 18% ) ,2 5例女性丙型病毒性肝炎患者阴道分泌物中HCVRNA阳性 9例 (3 6 0 % )。② 6例男性丙型病毒性肝炎患者精液HCVRNA阳性者配偶抗 HCV阳性1例 (16 67% ) ,9例女性丙型病毒性肝炎患者阴道分泌物HCVRNA阳性者配偶抗 HCV阳性 7例 (77 78% )。③ 72例性病患者生殖道分泌物HCVRNA阳性 4例 (5 5 % )。④对照组配偶抗 HCV均为阴性。结论 ①丙型病毒性肝炎患者精液、阴道分泌物中可检出HCVRNA ,丙型病毒性肝炎病毒存在性传播的可能性。②女性丙型病毒性肝炎患者性传播丙型病毒性肝炎病毒可能性比男性丙型病毒性肝炎患者要大。

Objective: To identify the possibility of the sexual transmission of hepatitis C virus(HCV). Methods: The samples of seminal fluid and of vagina secretion from patients with HCV infections were detected for HCV RNA by nested polymerase chain rection (NT?PCR) and their spouse were detected for anti?HCV by means of ELISA. healthy individuals together with their spouses were designed as acontraol. Results: ①33 samples of seminal fluid from patients with HCV infections, 6 (18 18%) were HCV RNA positives; 25 samples of vagina secretion from patients with HCV infection 9 ones(36 0%) were HCV RNA positives; ②anti?HCV was found in 1 spouse(16 6%) among 6, butin 6 ones HCV RNA positives were found from their samples of seminal fluid. Anti?HCV was found in 7 spouses(77 78%) among 9 ones, butin 9 ones HCV RNA positives were found from their samples of vagina secretion; ③4 (5 5%) out of 72 samples of secretion from patients with sexually transmitted diseases were HCV RNA positives. (4)No one had the markers of HCV in the control group. Conclusions: ①The study indicates that the possibility of the sexual trasmission of hepatitis C virus may occur, and that HCV RNA were found in seminal fluid and vagina secretion from patients with HCV infection; ②The possibility of HCV sexual transimission by women patients with HCV infections is more than man patients with HCV infections; ③The higher prevalence of HCV among sexually promiscuous groups was found.