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重组水蛭素药理学研究进展 被引量:56

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摘要 1955年Markwardt从医用水蛭咽周腺体中成功地分离出水蛭素纯品[1].
出处 《血栓与止血学》 2003年第1期31-34,共4页 Chinese Journal of Thrombosis and Hemostasis
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  • 1[1]Markwardt F. The development of hirudin as an antithrombotic drug. Thrombosis Research, 1994,74( 1 ): 1 ~ 23.
  • 2[2]Markwardt F. Hirudin and derivatives as anticoagulant agents. Thromb Heamost, 1991 ;66(1 ): 141 ~ 152.
  • 3[3]Vindigni V, Filippis VD, Zanotti G, et al. Probing the structure of hirudin from hirudinaria manillensis by limited proteolysis: isolation, characterization and thrombin-inhibitory properties of N-terminal fragments. Eur J Biochem,1994,226: 323 ~ 333.
  • 4李天全,万昌秀,李倚剑,陈槐卿.新一代高效特异抗凝药物——水蛭素[J].生物医学工程学杂志,1998,15(3):306-310. 被引量:21
  • 5[5]Nowak G, Markwardt F. Hirudin in disseminated intravascular coagulation.Haemostasis, 1991,21 (Supple 1 ): 142 ~ 148.
  • 6[6]Markwardt F, Kaiser B, Nowak G. Studies on antithrombotic effects of recombinant hirudin. Thromb Res, 1989,54(5) :377 ~ 388.
  • 7[7]Zawilska K, Zozulinska M, Turowiecka Z, et al. The effect of a long-acting recombinant hirudin (PEG-hirudin) on experimental disseminated intravascular coagulation (DIG) in rabbits. Thromb Res, 1993,69(3): 315 ~ 320.
  • 8[8]Doutremepuich C, Deharo E, Guyot M, et al. Antithrombotic activity of recombinant hirudin in the rat: a comparative study with heparin. Thromb Res,1989,54(5) :435 ~ 445.
  • 9[9]Talbot MD, Ambler I, Butler KD, et al. Recombinant desulphato-hirudin (CGP39393): anticoagulant and antithrombotic properties in vivo. Thromb Hemost, 1989,61 ( 1 ): 77 ~ 80.
  • 10[10]Bara L, Bloch MF, Sanana MM. A comparative study of recombinant hirudin and standard heparin in the Wessler modle. Thromb Res, 1992,68(2): 167~ 174.

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