应用硫普罗宁(凯西莱)治疗慢性肝炎的临床观察

Clinical evaluation on the effect of tiopronin treatment in chronic hepatitides

目的 观察注射用凯西莱 (硫普罗宁 )治疗慢性肝炎的临床疗效。方法 选择年龄 2 0～ 6 0岁 ,符合 2 0 0 0年 9月西安“病毒性肝炎防治方案”诊断标准的慢性肝炎患者 ,随机分为硫普罗宁 (凯西莱 )治疗组和还原型谷胱甘肽 (阿拓莫兰 )对照组 ,分别于用药前后观察临床症状及监测肝功能指标 :ALT、AST、SB。结果 硫普罗宁 (凯西莱 )治疗组较治疗前临床症状明显改善 ,血ALT、AST、SB下降 ,且与还原型谷胱甘肽 (阿拓莫兰 )对照组差异无显著性。结论 注射用凯西莱可有效改善慢性肝炎患者的临床症状和肝功能指标 。

AIM To evaluate the effect of tiopronin treatment in chronic hepatitides. METHOD 60 patients of chronic hepatitiedes were enrolled and randomized into tiopronin and atomolan groups. 30 patients were intravenous infused with tiopronin 0 2 plus 5% GS 500 ml daily for 2 weeks, 30 patients were intravenous infused with atomolan 1 2 g plus 5% GS 500 ml daily for 2 weeks. The efficacy was evaluated with live function from venous blood when pre treatment and post treatment respectively. RESULTS After 2 weeks, The liver function of almost all of the patients were improved remarkably. The parametens of ALT,AST,SB decreased obviously. And there was no difference between tiopronin and atomolan groups( P >0 05). CONCLUSION Tiopronin has remarkable effection in treating the patients with chronic hepatitides.