安神胶囊镇静催眠作用的研究

Study on sedative-hypnotic action of Anshen capsule

目的 研究安神胶囊的镇静催眠作用。方法 采用与戊巴比妥钠协同作用 ,强迫游泳“不动”法以及尾悬挂法等方法 ,观察安神胶囊的主要药理作用。结果 安神胶囊能明显延长戊巴比妥钠对小鼠的催眠作用时间 ,使戊巴比妥钠阈下催眠剂量所致睡眠动物数增加。结论 安神胶囊具有明显的镇静催眠作用 ,并且量效关系明显。

Objective To study sedative hypnotic action of Anshen capsule. Methods Methods of Anshen synergism with pentobarbital sodium, forced swimming,and tail hanging up were used to observe main pharmacodynamics of Anshen capsule.Results Anshen capsule could obviously prolong the sleeping time of mice produced by pentobarbital sodium, increase the quantity of sleeping animals caused by pentobarbital sodium in subthreshold hypnotic dose.Conclusion Anshen capsule produces obvious sedative hypnotic effect. The dose effect relationship is remarkable.