小鼠回肠黏膜固有层淋巴细胞在黏膜免疫应答中的形态学观察

Morphological observation of lamina propria lymphocytes of mice in mucosal immune response

目的 探讨回肠黏膜固有层淋巴细胞在抗原诱导下的黏膜免疫应答中的形态特征。方法 采用光镜和电镜方法 ,观察BALB/c小鼠灌服伤寒杆菌后回肠黏膜固有层淋巴细胞的组织学特征。结果 光镜下黏膜固有层可见形态各异的淋巴细胞。电镜下可见大量胞浆丰富而浅淡的淋巴细胞 ,有些淋巴细胞的突起穿越上皮的基膜 ,并可见大量浆细胞或浆细胞前体细胞 ,内质网丰富 ,可见其扩张形成囊泡和Russell小体。结论 伤寒杆菌可诱导小鼠回肠黏膜固有层淋巴细胞的免疫应答 。

Objective To study the morphological characterizations of lamina propria lymphocytes of ileum of mice in mucosal immune response under antigen inducement. Methods The histological characterizations of lymphocytes in lamina propria of ileum in BALB/c mice which took salmonella typhi were observed by light and electron microscopes.Results The various morphologies of lymphocytes were observed in lamina propria under light microscopy. Under electron microscopes, there existed a lot of lymphocytes which cytoplasm were plentiful and pale coloring, some lymphocytes were passing through basement membrane of epithelium. There existed some plasma cells or pre plasma cells which had plentiful and distended endoplasmic reticulum. Conclusion The salmonella typhi may induce the immune response of lamina propria lymphocytes in mice, and lamina propria is the effective site of the mucosal immune response.