慢性脊髓损伤的实验研究

Experimental study of chronic spinal cord lesion

目的 探讨慢性脊髓损伤的形成原因。方法 选用新西兰白兔 36只 ,随机分为 6组 ,即 1天、4月、8月造模组及相应对照组 ,造模组使用自制捆绑法固定兔于腰椎弯曲位来模仿人类的弯腰运动 ,通过体感皮层诱发电位及组织形态学等技术进行动态观察。结果 4、8月组造模动物白质出现了髓鞘变薄、水肿 ,粗大轴突的数量减少 ,细小的轴突相对增多 ,诱发电位潜伏期延长等慢性脊髓损伤的病理变化。

Objective To explore the cause of chronic spinal cord lesion.Methods In the experiment, 36 Newzenland rabbits were used and randomly divided into six groups: 1day, 4 month, 8 month experimental group and control group. The experimental group rabbits were fixed in flexion in self invented method to imitate the flexion of mankind.The SCEP and morphology changes were observed.Results In 4 month,8 month experimental groups,the chronic spinal cord lesion changes were found:thinning and swelling of myelin,decreasing of the number of large fibers,increasing of the number of small fibers,the latency of SCEP prolonged and so forth.Conclusion It indicates that both compression and traction are the reasons of chronic spinal cord lesion.