白细胞介素-12与新生儿感染的相关性研究

目的 :探讨白细胞介素 12 (IL 12 )与新生儿感染的关系及临床应用价值。方法 :采用酶联免疫 (ELISA )法 ,对新生儿感染 76例 (急性期及恢复期 )、对照组 (脐血 3 0例 ,正常新生儿静脉血 3 0例 )检测血清IL 2、γ IFN、IL 2、IL 6、IL 8水平。结果 :IL 12在新生儿感染急性期为 5 0 4 90± 46 5 8pg/L ,与恢复期 2 2 2 15± 3 3 67pg/L、正常新生儿组 2 2 9 96± 3 4 64 pg/L、正常脐血 2 15 60± 3 2 79pg/L。结果比较有显著性差异 ( P <0 0 1) ,各组IL 12与其他细胞因子呈正相关。结论 :IL 12等因子早期参与新生儿的免疫反应 ,检测IL 12可有助于新生儿感染的早期诊断 。

Objective To explore correlative between IL 12 and new-born babies infection and clinic use value.Methods adopting ELSA methods,We examined serum level of IL 2、γ IFN、IL 2、IL 6、IL 8 for 76 case of new born babies infection(a period of acute and a period of recovery)、Compare group(30 case of normal cord blood).Results in comparison there was statistical difference between a period of acute new born babies infection(504 90±46 58pg/L)and a period of recovery(222.15±33.67pg/L) and normal new-born babies(229 96±34 64pg/L),also normal cord blood (215 60±32 79pg/L)(P<0 001),IL 12 of groups is correlation related to other cytokines.Conclusion IL 12 early participates in immune reactive of new born babies.To examine IL 12 detecting new born infection,so as to find out of an effective wag of treating new born babies infection.