宫颈病变患者阴道菌群分布情况分析

The study of microbial population of vagina in patients with cervix uteri disease

目的 :了解宫颈病变的患者的阴道菌群分布情况 ,探讨宫颈不同病变对阴道微生态环境的影响。方法 :采用Mi croScanautoSCAN 4细菌鉴定系统分析 85例宫颈病变患者阴道分泌物中的分离出的菌株情况。结果 :共检出需氧菌 8种 ,主要检出的异常菌群为大肠埃希氏菌。宫颈有病变患者的乳酸杆菌检出率为 2 8 2 % ,大大低于文献报道正常体检妇女 (74 6% ) ,两者相比较 ,有显著性差异 (P <0 0 5 )。其异常需氧菌群的检出率为 3 6 5 % ,较文献报道正常体检妇女 (2 4 3 % )及阴道炎妇女(2 4 0～ 2 7 6% )高 ,有显著性差异 (P <0 0 5 )。宫颈非恶性病变患者与宫颈恶性病变患者的异常需氧菌群检出率分别为2 3 1% ,2 9 2 % ,差异无统计学意义 (P >0 0 5 ) ;阴道分泌物性质为血性、脓性者其阴道异常需氧菌群的检出率分别为 2 7 8% ,5 0 % ,差异无统计学意义 (P >0 0 5 )。结论 :宫颈病变可影响阴道的微生态环境 ,造成阴道内乳酸杆菌的大量减少 ,异常需氧菌群增加。

Objective:To explore the microbial population of vagina in patients with cervix uteri disease.Methods:McroScan auto SCAN 4 was used to detect the microbial population of vagina in 85 cases of patients with cervix uteri disease.Results:There were 8 difference microbial populations,the main non normal microbial populations is bacillus coil.The lactobacillus was discovered in 28 2% of patients with cervix uteri disease and was lower than that in normal control(74 6%)(P<0 05)(base on document report).The non normal microbial populations was discovered in 36 5% of patients with cervix uteri disease and higher than that in normal control(24 3%) and patients with vaginitis(24%～27 6%)(P<0 05)(base on document report).There was not difference in detectable rate of microbial population of vagina between patients with cervix uteri malignancy disease(23 1%) and benign disease(29 2%)(P>0 05).There was also not difference in detectable rate of microbial population of vagina between hemic secretary juice(27 8%) and purulent secretary juice(50%)(P>0 05).Conclusion:The vagina microeubiosis can be affected by cervix uteri disease and lactobacillus were significantly decrease and unusual aerobic bacteria were significantly increased.There was not difference in aerobic bacteria in vagina between the patients with cervix uteri malignancy disease and benign disease.