红丝线提取物对肾性高血压大鼠血压、一氧化氮和内皮素的影响

Effects of Peristrophe roxburghiana on Blood Pressure, NO and ET in Renal Hypertensive Rats

目的:观察红丝线提取物对肾性高血压大鼠血压、尿和血清中一氧化氮、一氧化氮合酶及内皮素浓度的影响。方法:采用两肾一夹高血压大鼠模型,连续灌胃给药4周,并于每周末测定血压;给药第4周末留尿测定尿一氧化氮含量,并处死动物取血测血清一氧化氮、一氧化氮合酶及内皮素的浓度变化。结果:红丝线灌胃1周后能使肾性高血压大鼠血压明显下降,血清中一氧化氮合酶以及尿和血清中一氧化氮浓度明显升高,而血浆中内皮素浓度明显降低。作用持续四周。结论:红丝线能降低肾性高血压大鼠的血压,升高一氧化氮合酶以及尿和血清中一氧化氮浓度,降低血浆中内皮素浓度。

Objective:To observe the effects of Peristrophe roxbrughiana( HSX) on blood pressure,NO,No-synthase and ET in the serum and NO in urine in renal hypertensive rats. Methods:The 2K1C(2 kidney 1 clap) hypertensive model rats were used and drugs had been given by ig. for 4 weeks. The blood prssure was measured at the end of the each week. At the end of 4 week, the urine was collected and the concentration of NO in the serum or urine, NO-synthease and ET in the serum were measured. Results: HSX (H or L dosage) by ig. for 1 week can significantly lower the blood pressure, increase the levels of NO and NO-synthase in the serum and NO in the urine, reduce the concentration of ET in the serum. The effects have lasted for 4 weeks. Conclusion:HSX played an important role in the renal hypertensive rats.