引起系统性红斑狼疮复发因素的病例对照研究

A case-control study on risk factors leading to recurrence of SLE

目的 了解易引起系统性红斑狼疮 (SLE)复发及防止复发的因素。方法 采用直接询问法 ,以 47名复发患者为病例组 ,以平稳期到医院定期检查的 55例SLE患者为对照组进行病例对照研究。结果 经单因素分析得出可能的危险因素是 :居住环境潮湿 (OR =2 75 ,P <0 0 1 )、不良性格 (OR =3 55 ,P <0 0 1 )、失眠 (OR =4 77,P <0 0 1 )、工作疲劳 (OR =3 52 ,P <0 0 1 )、周围人对患者态度不好 (OR =9 0 9,P <0 0 1 )、患病后不良心理状态 (OR =4 7,P <0 0 1 )、医护人员态度不好 (OR =6 63 ,P <0 0 1 )、颧部红斑(OR =3 0 5 ,P <0 0 1 )、而严格按医嘱服用激素为预防因素(OR =0 1 2 ,P <0 0 0 0 1 )。经Logistic回归分析得出只有失眠、周围人对患者态度不好、患病后不良心理状态为有意义的危险因素 ,严格按医嘱服用激素为有意义的预防因素。结论 失眠、周围人对患者漠不关心、歧视和避而远之、患者不良心理状态可能是引起SLE复发的危险因素 。

Objective To discover risk and protective factors that could lead to recurrence of systemic lupus erythematosus (SLE). Methods A case control study based on self report was carreid on in 47 SLE patients of recurrence and 55 inactive SLE patients who came to see a doctor at regular intervals. Results Uni variable test revealed that possible risk factors were moist living circumstance, bad disposition, insomnia, frequent fatigue from work,felt unkindness of others, abnormal psychological status, doctors and nurses’unkindness and malar rush. The risk fact ors selected by Logistic regression were insomnia, others' unkindness and abnormal psychological status. Taking prednisone according to specialist was a protective factor. Conclusion The result indicates that SLE recurrence is most strongly associated with insomnia, others’unkindness and abnormal psychological status. Taking prednisone according to specialist is a protective factor.nkindnessofothers,abnormal