川芎嗪对风心病瓣膜置换围术期血液流变性改善作用

Hemorheologic improvement by tetramethylpyrazine on patients in perio perative period of valvesreplacement due to rheumatic heart disease

目的 探讨风心病瓣膜置换围术期血液流变学变化及川芎嗪对其改善作用。方法 选取风心病瓣膜置换术患者 50例 ,随机分成川芎嗪实验组和对照组 ,监测围术期血液流变学指标。结果 实验组及对照组全血黏度、血浆黏度、红细胞聚集指数和变形指数均发生改变。实验组指标改善明显。结论 川芎嗪对风心病瓣膜病变患者围术期血液流变性有改善作用 ,可减少围术期并发症的发生 ,提高手术的安全性和成功率 。

Objective To study the hemorheologic changes and improvement of tetramethylpyrazine on valves replacement of rheumatic heart disease in perioperative period. Methods Fifty patients suffering from rheumatic hear t disease and needing valves replacement were randomly divided into treatment gr oup and control group. Hemorheologic indicators were individually measured in pe rioperative period. Results There were many changes in blood viscosity, plasma viscosity,erythrocyte aggregation index,erythrocyte deformity index in treatment group and control group.In treatment group ,these indicators improved significantly. Conclusion Tetramethylpyrazine plays a role in improving hemorheology,reducing complication,raising operative reliability and suc cess rate and has no obvious side effect on valves replacement of rheumatic hea rt disease in perioperative period.