谷氨酸拮抗剂对抗梭曼所致惊厥的研究进展

Research progress of glutamate antagonist against soman-induced convulsion

梭曼中毒 ,可导致惊厥。惊厥发生后 ,谷氨酸大量增多 ,从而使惊厥得以维持、延续并引起中枢神经系统病理学改变。谷氨酸拮抗剂 ,通过抑制突触前谷氨酸释放及作用于突触后谷氨酸的相应受体 ,发挥抗惊及神经保护作用。本文将对不同类型的谷氨酸拮抗剂抗梭曼致惊疗效。

As a result of soman poisoning_induced convulsion, greatly increased glutamate leads to the continuation and maintenance of seizure and the pathology of CNS. The glutamate antagonist takes its effectiveness against the soman_induced convulsion and keeps the neuronal cells from damage through the restraint of release of presynaptic glutamate and action on its right receptors. The effectiveness against the soman_induced convulsion, mechanism and applications of different kinds of glutamate antagonist are reviewed.