四(2-甲氧基异丁基异腈)络铜(Ⅰ)氟硼酸盐的合成和^(99)Tc^m-2-甲氧基异丁基异腈制备研究

THE SYNTHESIS OF TETRA (2-METHOXY ISOBUTYL ISONITRILE) CUPROUS BOROFLUORIDE AND THE PREPARATION OF ^(99)Tc^m-MIBI

本文报道了四[2-甲氧基异丁基异腈]络铜(Ⅰ)氟硼酸盐(Cu(MIBl)_4BF_4)的合成和心肌灌注显像剂^(99)Tc^m-2-甲氧基异丁基异腈(^(99)Tc^m-MIBl)的制备研究及初步动物实验结果。Cu(MIBI)_4BF_4是一白色晶体,经IR,NMR,MS和元素分析等测定,结果与结构完全一致。讨论了pH值、Cu(MIBI)_4BF_4用量、FSA用量及^(99)Tc^mO_4^-洗脱液体积、加热时间对^(99)Tc^m-MIBI标记率的影响。以Cu(MIBI)_4BF_4为原料制成的一步法冻干药盒,标记率大于90％,经动物实验和初步临床应用,证明该药盒使用简单方便,稳定性好,是很有前途的心肌灌注显像剂。

The synthesis of Cu(MIBI)4BF4, the preparation of 99Tcm-MIBI and the animal studies are reported in this paper. Cu(MIBI)4BF4 is a white solid. The IR,NMR,MS and elementary analysis are consistent with the structure of Cu(MIBI)4BF4. It also discusses the effects of pH value, weights of Cu(MIBI)4BF4 and FSA,volume of 99TcmO4- solution and heating time on the labelling yields of 99Tcm- MIBI. From the kit made of Cu(MIBI)4BF4 ,the labelling yields of 99Tcm-MIBI are over 90%. The animal studies and preliminary clinical application are proved that 99Tcm-MIBI is a potentially useful myocardial perfusion imaging agent.