用一或二份血样本^(131)I-OIH血浆清除法测定肾有效血浆流量

Measurement of effective renal plasma flow by plasma clearance of ~131I -Hippuran using one or two blood sampling

研究了29例病人注射^(131)I—OIH后10—90min内获取6份血浆标本作清除曲线,用双室模型分析计算出ERPF作为参考标准。单份49min样本代替完整清除曲线所得结果的标准估计误差(Sy-x)为65.6ml/min,而两样本法(10和90min)的Sy·x可减小到20.7ml/min。

Twenty nine patients were studied by obtaining six plasma samples for each clearance curve at 10 to 90 min after injection as a reference standard. ERPF has been calculated from a two-compartment model analysis (Sapirtein Method). The standard error of estimate (Sy.x) by single 49 min sample was 65.6ml/min. By using two samples (at 10 and 90 min), Sy.x-could be reduced to 20. 7ml/min.