摘要
采用(-)^(125)I-心得静为特异配基的β受体结合分析研究表明,知母可抑制甲亢小鼠模型心肌β受体数的增加。用BAlpM不可逆阻断已存在的β受体后,测定不同时间间隔心肌细胞膜β受体数,计算出各动力学参数。知母可使甲亢小鼠心肌β受体生成速率降低48％;降解速率常数降低35％。知母对生成的抑制超过对降解的抑制,结果使甲亢模型的β受体数显著降低,接近正常值。
Radioligand binding assay of receptors with 1251 - iodopindolol revealed that Zhimu can siginificantly inhibit the increase of mouse heart β - adrenoceptors induced by T3. The kinetic parameters were calculated from the data of heart β- adrenoceptor binding sites determined at various periods after irreversible blocking of the preexisting β- adrenoceptors. Zhimu can decrease the production rate and degradation rate constant of hyperthyroid mice by 48 % and 35% respectively. These results indicate that Zhimu can decrease the production rate more potently than the degradation rate of heart β - adrenoceptors in hyperthyroid mice, and hence can make the number,of receptor binding sites approach normal.
出处
《核技术》
CAS
CSCD
北大核心
1992年第11期651-655,共5页
Nuclear Techniques
基金
国家自然科学基金
关键词
Β受体阻断药
知母
甲状腺疾病
β- adrenoceptors Turnover Hyperthyroidism Zhimu Irreversible antagonist
