放射性^(125)I粒子永久植入联合吉西他宾/5Fu治疗局部进展期胰腺癌初步观察

IMPLANTED ^(125) I RADIOACTIVE SEEDS INTO TUMOR COMBINED WITH CHEMOTHERAPY TO TREAT EXTENDED LOCAL PANCREAS CANCER

目的 :探讨放射性12 5I粒子植入联合化疗治疗进展期胰腺癌的临床价值。方法 :前瞻性随机分组分析放射性12 5I粒子永久植入联合化疗治疗进展期胰腺癌 18例疗效 ,毒副反应及生存率。结果 :放化疗组CR +PR达 38.9% (2 +5 / 18) ,对疼痛控制疗效显著 (77.8%对 5 0 .0 % ) ,与对照组比较有显著性差异 (P <0 .0 5 )。术后 6个月 ,12个月生存率及中位生存时间显著提高。结论 :放射性12 5I粒子植入联合化疗对进展期胰腺癌 ,能控制肿瘤生长 ,缓解疼痛 ,改善患者生活质量。是一种安全有效的肿瘤综合治疗手段。

Objective:Exploring the significance of implanted 125 I radioactive seeds into tumor combined with chemotherapy to treat extended local pancreas cancer.Method:Cure results, side effect and survival of 18 cases extended local pancreas were randomized analyzed by prespectively. Result:CR+PR of radio and chemotherapy was 38.9%(2+5/18); effect of relieve pain was inproved apparently (77.8%对50.0%). The difference between the two groups was statistically significant ( P <0. 05) .Survival of 6, 12 months and middle survival time were improved. Conclusion:Implanted 125 I radioactive seeds into tumor combined with chemotherapy to treat extended local pancreas cancer can control tumor enlarge, relieve pain and improve life quality. It is a safe and effective method.