21℃海水浸泡对创伤失血性休克大鼠血液动力学的影响

HEMODYNAMIC CHANGES OF HEMORRHAGIC SHOCK IN RATS WITH 21℃ SEAWATER IMMERSION

目的 :探讨 2 1℃海水浸泡失血性休克大鼠时血液动力学的变化。方法 :采用Wister雄性大鼠 2 1只 ,随机分为平原失血性休克组 (n =10 )、海水浸泡失血性休克组 (n =11)。运用四道生理记录仪监测动物伤前及休克终点、10 ,30 ,6 0 ,180 ,30 0min时血液动力学的变化。结果 :海水浸泡动物早期血压升高 ,但很快下降 ,并且显著低于陆地失血性休克动物 ;海水浸泡失血性休克动物血液动力学显著低于陆地失血性休克组动物 ,入水30 0min时±dp/dtmax、LVSP ,HR ,MAP ,RR仅为陆地失血性休克动物的 5 9% ,5 6 .5 % ,4 1.6 % ,5 7.8% ,4 3.4 %。结论 :2 1℃海水浸泡失血性休克动物血液动力学状态明显恶化 ,动物死亡率明显增大。

Objective:To observe the hemodynamic changes of hemorrhagic shock rats immersed in 21℃ seawater. Methods:Twenty-one rats were divided randomly into two groups: plane hemorrhagic shock group, seawater immersion hemorrhagic shock group. The hemodynamic changes were recorded by four-channel physiologic recorder in control and 0, 10, 30,60,180,300min after shock. Results:MAP of rats with 21℃ seawater immersion was elevated in the early stage and then declined quickly. The hemodynamic level of rats with seawater immersion was significantly lower than that of the plane hemorrhagic shock. At 300min after seawater immersion,± dp/dt max , LVSP, HR, MAP and RR decreased to 59%,56.5%,41.6%,57.8%,43.4% of plane hemorrhagic shock level.Conclusion:The 21℃ seawater immersion can markedly produce the hemodynamic derangements and increase mortality of rats.