正常前列腺和良性前列腺增生组织成分的图像分析研究

Analysis of computer-assisted quantitative image on histomorphology of the normal prostate and benign prostatic hyperplasia

目的 :探讨正常前列腺 (NP)和良性前列腺增生 (BPH)组织中病理组织学改变的关系。方法 :应用HE染色和计算机辅助图像分析的方法 ,对 7例正常前列腺和 30例前列腺增生患者前列腺组织进行组织形态学定量分析。结果 :①BPH前列腺组织中间质、腺体、上皮和腺腔的面积百分比分别为 :(62 .1 8± 8.1 4 ) % ,(38.72± 7.0 2 ) % ,(1 7.96± 4 .0 3) %和 (1 9.80± 6 .39) %。间质与腺体的比例为 (1 .70± 0 .58)∶1 ,与正常组织相比比例显著增高 (P <0 .0 5) ;间质与上皮的比例为 (3 .70± 1 .2 4 )∶1 ,与正常组织相比比例显著增高 (P <0 .0 1 ) ;②随前列腺体积增加 ,间质面积百分比下降 ,而腺体、上皮、腺腔的面积百分比增加。结论 :良性前列腺增生以间质增生为主 ,腺体增生以腺腔的扩张较为显著 ;随前列腺体积增加 ,间质面积百分比下降 ,而腺体、上皮、腺腔的面积增加。

Objective:To investigate the histomorphology of normal prostate(NP) and benign prostatic hyperplasia(BPH).Methods:Computer-assisted quantitative image analysis was used to determine the histomorphology of 7 specimens of NP and 30 specimens of BPH with HE staining.Results:①The percentage of stroma, gland, epithelia and lumina in BPH were (62.18±8.14)%,(38.72±7.02)%, (17.96±4.03)% and (19.80±6.39)%, respectively. The ratios between stroma/ gland and stroma/ epithelia were (1.70±0.58)/ 1 and (3.70±1.24)/ 1, respectively, which were significately increased in comparison with that of NP ( P <0.05 and P <0.01,respectively). ②As the prostate volum increased, the percentage of stroma area was decreased, and the percentage of gland, epithelia and lumina area was increased.Conclusion:The hyperplasia is mainly occurred in stroma tissue in BPH. As the prostate volum increased, the percentage of stroma area is decreased, the percentage of gland, epithelia and lumina area are increased. The hyperplasia of stroma probably is the basis of the other tissues hyperplasia.