老年慢性阻塞性肺疾病(急性发作期)糖代谢改变的临床分析

Clinical Analysis on the Changes of Glucose Metabolism of Senile Chronic Obstructive Pulmonary Disease(SCOPD)during Acute Exacerbation

[目的 ]了解老年慢性阻塞性肺疾病 (SCOPD)急性发作期血糖及胰岛素的变化 ,分析慢性阻塞性肺疾病糖代谢改变的原因。 [方法 ]采用口服葡萄糖耐量试验、胰岛素释放试验检测 3 2例老年 SCOPD急性发作期患者治疗前后血糖和胰岛素水平 ,并与健康对照组比较 ,同步检测动脉血的血气分析。 [结果 ]SCOPD急性发作期患者各时点血糖水平显著高于缓解期和对照组 (P <0 .0 1 ) ,SCOPD发作期胰岛素水平显著低于缓解期和对照组 (P <0 .0 5 )。 [结论 ]SCOPD急性发作期患者存在着糖代谢异常 。

To investigate the changes and insulin in patients with SCOPD during the acute exacerbation.The plasma glucose and insulin level of 32 cases with SCOPD during acute exacerbation were measured with oral glucose tolerance test(OGTT) and insulin release test (IRT) before and after treatment,and compared with the control group,and synchronously the artery blood was examined and analyzed.The blood sugar level at each hour of the exacerbation period shows obviously higher than that of the alleviating period and that of the control group(P<0.01);the insulin level at each hour of the exacerbation period shows obviously lowver than that of the alleviating period and that of the control group(P<0.01).[Conclusion]Abnormal glucose metabolism exists in SCOPD during acute exacerbation,which may be related to insufficient secretion of insulin.