仙人掌汁外用对变应性接触性皮炎的影响

Effect of cactus liquor on allergen contact dermatitis in guinea pigs.

目的 了解仙人掌对皮炎湿疹类疾病的作用及其机制。方法 以豚鼠变应性接触性皮炎(ACD)作为动物模型,仙人掌汁外用,观察其皮肤反应强度、病理变化及真皮有核细胞浸润数。结果 皮肤反应强度比较,实验组与地塞米松组无显著性差异(P>0.05),而与对照组比较,有极显著性差异(P<0.01);真皮有核细胞浸润数,实验组与另两组比较其值均有极显著性差异(P<0.01),地塞米松组作用更强。结论 仙人掌汁外用对豚鼠ACD有显著的抑制作用,能减轻炎症反应强度,减少有核细胞浸润的数目。

Objective To study the effect and mechanism of cactus in the treatment of dermatitis and eczema. Methods Guinea pig model of allergen contact dermatitis was used. Cactus liquor was brushed on the lesion. The response intensity of skin, pathologic changes and infiltration of nucleus cells in the corium were observed. Results There was no significand difference in the response intensity of the skin between the experimental group and dexamethasone group (P>0.05), while there was very significant difference between the experimental group and control group (P<0.01). There was very significant difference in the infiltrated nucleus cell counts between the experimental group and any other groups (P<0.01). Conclusion External use of cactus liquor had distinct restrain for ACD in guinea pig, could alleviate the intensity of inflammatory response and the infiltration of nucleus cells.