非吸烟女性肺癌与血浆谷胱甘肽转移酶和一氧化氮相关性研究

A Study of Relationship between GST and NO of Serum and Lung Cancer in Female Non-smoker

[目的]研究非吸烟女性肺癌与血浆谷胱甘肽转移酶(GST)和一氧化氮(NO)的相关性,寻找女性肺癌的发病因素。[方法]搜集经病理确诊的原发性非吸烟女性肺癌病例30例,进行1∶1配对病例对照研究,流行病学调查内容包括:一般状况、家族史、疾病史、居住史、职业史、被动吸烟史、饮食史、烹饪史、室内微小环境污染史、并测定其血浆GST和NO水平。[结果]非吸烟女性肺癌以腺癌为主(53.30%),中位年龄57岁。流行病学调查中的诸因素与非吸烟女性肺癌未见相关性(P>0.05)。病例组血浆GST为(64.42±24.71)U/ml,高于对照组的(25.28±5.21)U/ml,两组比较有显著性差异(P<0.01)。病例组血浆NO为(105.71±25.68)μmol/L,高于对照组(78.38±15.78)μmol/L,两组比较有显著性差异(P<0.05)。[结论]血浆GST和NO的水平增高可能与非吸烟女性肺癌相关。

To study the relationship between GST and NO in serum and lung cancer in female non-smok-ers.An1∶1matched case-control investigate was carried out in shenyang.An epidemiological questions covering demography,family history of cancer,previous disease history,living conditions passive smoking,occupational exposure,di-et/nutritional preferences,cooking habits,sources of indoor pollution and so on were used to ask each subject,and GST,NO in serum were detected by chemical methods.Thirty new cases diagnosed as primary lung cancer and30female non-smoker controls matched for age,sex and residential quarter were enrolled in this study.The mean age was57years old,and adenocarcinoma was the main type of female lung cancer accounting for53.30%.There was no significant difference on epidemiological investigate with univariate analysis between both groups(P>0.05).There were significamtly higher of GST(64.42±24.71)U/ml and NO(105.71±25.68)μmol/L in female lung cancer than those in controls(25.28±5.21)U/ml,(78.38±15.78)μmol/L(P<0.01,P<0.05).[Conclusions]There are a relationship between increased GST and NO in serum and female non-smoker and with lung cancer.