卡维地洛对心力衰竭的治疗作用

Effects of carvedilol on heart failure

目的 明确新型肾上腺素受体阻滞剂卡维地洛在心力衰竭治疗中的价值。方法 3 0只 Wistar大鼠随机分为3组 ,分别进行空白处理 ( A组 ,对照组 )、过度游泳训练 8周 ( B组 ,心力衰竭组 )、过度游泳训练 8周后服卡维地洛3 m g· kg- 1 · d- 1 8周 ( C组 ,卡维地洛组 ) ,经 16周后 ,测血流动力学指标、心肌细胞凋亡率、左心室质量指数、心肌间质纤维化程度等。结果 各项指标比较 ,A、B组各项指标均有显著差异 ;B、C组间血流动力学指标无显著差异而心肌细胞凋亡率有显著差异。结论 卡维地洛对心肌细胞有保护作用 。

Objective To make clear curative effects of carvedilol, a new adrenergic receptor blocker in heart failure. Methods 30 Wistar rats were randomly divided into three groups : Control group(Group A); Heart failure group(Group B), which do over-swimming exercise for 8 weeks; Carvedilol group(Group C),which do over-swimming exercise for 8 weeks and taken Carvedilol orally 3mg·kg -1·d -1for 8 week afterwards; 16 weeks later indexes were measured as hemodynamics, myocardic apoptosis rate, left ventricular mass index (LVMI), myocardic interstitial fibrosis etc. Results According all indexes above, there is remarkable difference between Group A and Group B,apoptosis rate of Group C is different to that of Group B while no remarkable difference between them is found when it is to hemodynamics, LVMI and myocardic interstitial fibrosis. Conclusion Carvedilol is beneficial in protecting myocardium. Perhaps patients with heart failure treated with Carvedilol have favorable prognosis.