生长激素与生长抑素联合治疗重症急性胰腺炎

Effects of Recombination Growth Hormone and Somatostain in The Treatment of Serve Acute Pancreatitis

目的:研究生长激素与生长抑素联合对重症急性胰腺炎的治疗作用。方法:本组重症急性胰腺炎(SAP)40例,联合应用生长激素和生长抑素组与单用生长抑素组各20例,两组生长抑素醋酸盐用量分别为76±13 mg和78±14 mg,前者重组人生长激素用量8 u·d^(-1),共7～10 d。观察两组患者临床疗效及营养和免疫状况。结果:联合用药组与单用生长抑素组平均住院时间分别为34±4.1 d和48±3.8 d(P<0.05),各脏器严重并发症出现率分别为35％和75％(P<0.05,死亡率分别为10％和20％。治疗后10 d,联合用药组的血清白蛋白浓度和CD_4/CD_8均显著高于单用生长抑素组(P<0.05)。结论:联合应用生长激素和生长抑素治疗,有助于提高SAP患者的疗效,减少其并发症。

OBJECTIVE: To explore the effect of recombination human growth hormone(rhGH) and somatostain(SS) in the treatments of serve acute pancreatitis (SAP). METHODS: Fourty critical patients were divided randomly into rhGH+SS(20 cases) and SS treatment group(20 cases), and a total of 76 ± 13 mg and 78±14 mg somatostain were given in these two groups, respectively. Patients in rhGH+SS group were given growth hormone 8u·d-1 intromuscularly for 7 - 10 days. RESULTS: The average hospital stay days (34 ± 4.1) and complication ocurrence rate(35%) of the rhGH+SS group were lower than these (48 + 3.8d, 75% ) of the SS group (all P<0.05). The mortalities of the rh GH+SS and SS groups were10 % and 20 % respectively ( P>0.05). The serum level of albumin and the ratio of CD4/CD8(cluster of differentiation) increased significantly in the GH+SS group after 10 days of treatment (P<0.05 ). CONCLUSION: The combination of rhGH and SS improve the clinical effect in treatments of serve acute pancreatitis treatment.