用体外代谢数据预测临床上药物体内代谢性相互作用

Prediction of Metabolic Drug Interaction in vivo by Using in vitro Drug Metabolism Data

用体外代谢数据可以预测临床上药物体内代谢的相互作用。本文介绍其中一些重要概念、预测模型、方法及影响预测准确性的因素。

The potentials of metabolic drug interactions in vivo can be predicted by using in vitro metabolism data. This review describes some key concepts in this respect, predictive models, procedural details and the factors which reduce the predictability.